Recent Technical Updates pg 24

SUB ACUTE SCLEROSING PAN ENCEPHALITIS DESPITE ADEQ ...

When SSPE occurs in immunised children, it is thought to result from a subclinical measles infection that occurred before 9 months of age, when immunisation usually begins. Although rare, this case is ...Source: The Australasian Medical Journal

SUBACUTE SCLEROSING PANENCEPHALITIS PRESENTING AS ...

In this case report, the authors document clinical progress in a child in which there were atypical features simulating that of neuromyelitis optica but as the disease progressed, characteristic myocl ...Source: BMJ Case reports

ATYPICAL CLINICAL COURSE SUBACUTE SCLEROSING PANEN ...

SSPE should be considered when a patient with measles history is admitted because of atypical clinical features like loss of consciousness, acute partial-generalized convulsion, acute-subacute coma, v ...Source: Journal of Paediatric Neurosciences

TOWARDS THE ENDGAME AND BEYOND: COMPLEXITIES AND C ...

A highly contagious childhood viral infection, measles remains one of the leading causes of death of children under 5 years of age despite the existence of an affordable and effective vaccine. Th ...Source: Philosophical Transactions of Royal Society of London, Series B, Biological sciences

CHILDHOOD IMMUNIZATION: WHEN PHYSICIANS AND PARENT ...

In this article, we learn that health providers must inquire about childrens and parents beliefs in a respectful manner, maintain an open and understanding relationship with families, and use their ro ...Source: Journal of Paediatrics

THE AGE OLD STRUGGLE AGAINST THE ANTIVACCINATIONIS ...

In perspective, Gregory A et al report that there has been opposition to vaccination since the introduction of the first vaccine. Fear and mistrust have arisen every time a new vaccine has been introd ...Source: The New England Journal of Medicine

CLINICAL TESTING OF ENGINEERED ONCOLYTIC MEASLES V ...

This article describes the use of strains of the attenuated measles virus Edmonston (MV-Edm) vaccine lineage to preferentially infect and destroy cancerous cells while sparing the surrounding tissues. ...Source: Medicine Sciences

ATTENUATED MEASLES VIRUS USED AS AN ONCOLYTIC VIRU ...

Jean-François Fonteneau et al present data which shows that attenuated strains of measles virus induce an immunogenic cell death of tumor cells capable of activating myeloid and plasmacytoid de ...Source: Oncoimmunology

NATURAL ONCOLYTIC ACTIVITY OF LIVE-ATTENUATED MEAS ...

Nicolas Boisgerault et al report on their experiment that tested the ability of live-attenuated Schwarz strain of measles virus to specifically infect tumor cells derived from human lung and colorecta ...Source: Biomed Research International

TREATMENT OF MEDULLOBLASTOMA USING AN ONCOLYTIC ME ...

Brian Hutzen et al report on the use of oncolytic measles virus that encodes the human thyroidal sodium iodide symporter to deliver targeted radiotherapy to the localized or metastic medulloblast ...Source: BMC Cancer

EFFECTIVE RADIOVIROTHERAPY FOR MALIGNANT GLIOMAS B ...

In this study, genetically engineered measles virus strains that express the human sodium iodide symporter (NIS) are shown to have significant antitumor activity against glioma lines and orthotopic xe ...Source: Human Gene Therapy

ENGINEERED MEASLES VIRUS EDMONSTON STRAIN USED AS ...

In this article, Shu-Cheng Zhang et al report on an attenuated strain of measles virus, derived from the Edmonston vaccine lineage, was genetically engineered to produce carcinoembryonic ant ...Source: BMC Cancer

EFFECT OF INTERMITTENT PREVENTIVE TREATMENT FOR MA ...

The implementation of the WHO recommendation to integrate intermittent preventive treatment of malaria during infancy (IPTi) has been slow. This article elucidates the conceptual and theoretical fears ...Source: Lancet

ACCEPTABILITY OF COUPLING INTERMITTENT PREVENTIVE ...

This paper presents multi-country data on community perceptions and acceptability of integrating intermittent preventive treatment for malaria during infancy (IPTi) into routine immunizations. Notwith ...Source: Tropical Medicine and International Health

INCREASE IN EPI VACCINES COVERAGE AFTER IMPLEMENTA ...

A cluster randomized control trial demonstrating that intermittent preventive treatment for malaria during infancy (IPTi) significantly contributes to routine immunization coverage. In the global vacc ...Source: BMC Public Health

MEASLES.

Having lived to see the devastating effects of measles infection, I cannot agree more with the desired aspiration  to protect all future generations against measles infections. In this article, W ...Source: Lancet

MEASLES VIRUS, IMMUNE CONTROL AND PERSISTENCE.

Did you know that measles infection is initiated in the respiratory tract followed by rapid spread of virus to local lymphoid tissue and then to multiple other organs? Did you know that it is the imma ...Source: FEMS Microbiology Reviews

PROLONGED PERSISTENCE OF MEASLES VIRUS RNA IS CHAR ...

Prolonged RNA presence in infected childre for long was associated with high risk of SSPE. This article provides experimental details that show that viral RNA persists in blood, respiratory tract or l ...Source: Proceedings of the National Academy of Sciences of the United States of America

MEASLES VIRUS-INDUCED SUPPRESSION OF IMMUNE RESPON ...

Would you like to know why measles virus is candidate material for cancer treatment? Its all about using measles-induced immune suppression of immune responses. Although measles virus infection is kno ...Source: Epidemiological Reviews

ESTIMATES OF MEASLES CASE FATALITY RATIOS: A COMPR ...

That measles infection kills, and more so in early childhood, is not the challenge. The fact that in this day and age, we are still as imperfect as our fore fathers were in predicting war, should worr ...Source: International Journal of Epidemiology

MEASLES CASE FATALITY RATIO IN INDIA A REVIEW OF C ...

This paper presents a full text review of measles case fatality ratios (CFR) from community based studies in India. Paper shows variations in measles CFR over time and rural/urban populations. Interes ...Source: Indian Paediatrics

DECLINE IN MEASLES CASE FATALITY RATIO AFTER THE I ...

Full text documentation of measles case fatality ratios (CFR) in two time periods that had variations in measles immunization coverage. Paper shows that severity and fatality of measles infections dec ...Source: American Journal of Epidemiology

CHALLENGES IN MEASURING MEASLES CASE FATALITY RATI ...

Full text documentation of a retrospective study method of determining measles case fatality ratios (CFR) in a setting without vital registration systems. Challenges not withstanding, the approach use ...Source: Emerging Themes in Epidemiology

OUTBREAKS ASSOCIATED TO LARGE OPEN AIR FESTIVALS, ...

Preparing for the Hajj next month or the FIFA World cup in 2014? Measles vaccination  ought to be on your preparedness planning. This is a full text review of documented outbreaks that followed l ...Source: Euro Surveillance and Outbreaks Report

ANALYSIS OF NATIONAL MEASLES SURVEILLANCE DATA IN ...

Full text documentation of measles outbrreaks in Italy shows that there are still major challenges to the country’s 2015 elimination goals, as in the rest of Europe. Paper calls on all countries ...Source: Euro Surveillance and Outbreaks Report

WAS THERE A DISPARITY IN AGE APPROPRIATE INFANT IM ...

Full text documentation of using contacts quarantine as a strategy for reducing measles reproduction rate.  Is there enough evidence to support identification and quarantine of non-vaccinated con ...Source: BMC International Health and Human Rights

GUIDELINES FOR THE DOCUMENTATION AND VERIFICATION ...

Knowing what it takes to document measles and Rubella/CRS elimination is critical to the attainment of the goals. This full text description of the three criteria that guide verification of measles an ...Source: Journal of Infectious Diseases

ELIMINATION OF RUBELLA AND CONGENITAL RUBELLA SYND ...

Full text description of interventions used to eliminate Rubella and Congenital Rubella Syndrome. Emphasis is put on wide age supplemental immunization with RCV, introduction of the vaccine into routi ...Source: Journal of Infectious Diseases

RUBELLA ELIMINATION, THE CANADIAN EXPERIENCE

Full text description of Rubella elimination in Canada. Emphasis on use high quality Rubella containing vaccination campaigns, effective case-based surveillance for rubella cases and pockets of unimmu ...Source: Journal of Infectious Diseases

LESSONS LEARNED FROM INTEGRATED SURVEILLANCE OF ME ...

Measles and Rubella are diseases of different aetiology and clinical progression. However, surveillance for both diseases can effectively be integrated. Full text description of a system that was desi ...Source: Journal of Infectious Diseases

WANING OF MATERNAL ANTIBODIES AGAINST MEASLES, MUM ...

Is there something we did not know about high measles coverage, in our quest for herd immunity? Waaijenborg Sandra at the National Institute of Public Health and the Environment, Centre for Infectious ...Source: Journal of Infectious Diseases

MOVING FORWARD WITH STRENGTHENING ROUTINE IMMUNIZA ...

As evidence mounts that the elimination of measles is faltering, Rebecca fields et al. in a review article enthuses us that using the decade of vaccine commitments, we can still move forward to see me ...Source: Vaccine

CHALLENGES AND TARGETS FOR MEASLES ELIMINATION.

As evidence mounts that the elimination of measles is faltering, Talha Burki looks at the scale of the problem worldwide, and what is being done to fight back against the disease. More details are ava ...Source: Lancet

WAS THERE A DISPARITY IN AGE APPROPRIATE INFANT IM ...

Full text documentation of measles outbrreak in a post conflict district in which age-appropriateness of infant immunizations and not coverage is the single most important risk factor. Therefore MCV c ...Source: BMC International Health and Human Rights

EPIDEMIOLOGY AND CLINICAL CHARACTERISTICS OF THE M ...

Full text documentation of measles outbrreak in the Nylon district of Douala in Cameroon. As in other other outbreaks, low routine measles vaccination coverage is the single most important risk factor ...Source: Pan African Medical Journal

HISTORICAL DATA AND MODERN METHODS REVEAL INSIGHTS ...

This is a full text documentation of measles epidemiology in a pre-vaccination context. A low measles reproduction rate and a shorter mean clinical serial interval than is generally reported. More det ...Source: BMJ Open

MEASLES MORTALITY REDUCTION CONTRIBUTES SUBSTANTIA ...

Full text documentation of 23% reduction in all cause mortality reduction attributable to accelerated measles control efforts. Arguably, failure to sustain measles control gains is a risk to attainmet ...Source: Journal of Infectious Diseases

QUANTIFYING CHILD MORTALITY REDUCTIONS RELATED TO ...

 Full text review of historical immunization coverage and associated measles mortality reductions document that 95% measles ccoverage is needed to attain 95% mortality reduction goals. Notably, 9 ...Source: PLoS One

UNACCEPTABLY HIGH MORTALITY RELATED TO MEASLES EPI ...

As the world documented the unprecendented 86% measles mortality,  the risk lies in failing to deal with high mortality rates that continue to occur in outbreak settings. Full text details on hig ...Source: PLoS One

AGE-APPROPRIATE VACCINATION AGAINST MEASLES AND DP ...

Full text description of  the relevance of adherence to national immunization schedule for measles. Results of this study show that premature measles vaccination is rampant in India and could acc ...Source: BMC Public Health

IMMUNOLOGICAL IMPACT OF AN ADDITIONAL EARLY MEASLE ...

Full text description of  a study that shows that giving measles vaccines at 4 months of age induced a predominantly CD4 T-cell response at 9 months and rapid development of high antibody concent ...Source: Vaccine

NON-SPECIFIC EFFECTS OF STANDARD MEASLES VACCINE A ...

Full text description of the beneficial effects of two measles vaccination doses, especially to girl children than boys. Is it time for gender specific immunizzation schedules of this is coincidental? ...Source: British Medical Journal

PROTECTIVE EFFICACY OF STANDARD EDMONSTON-ZAGREB M ...

Increasingly, more countries are adopting the recommendation to use two-dose schedules for measles vaccination in their outine programs. Do we need then to keep first measles vaccination at 9 months a ...Source: British Medical Journal

THREE CASES OF CONGENITAL RUBELLA SYNDROME IN THE ...

Documented imported CRS cases into the US from Africa are documented here. Full text details are available at: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6212a3.htm?s_cid=mm6212a3_w Abstract Since 2 ...Source: Morbidity and Mortality Weekly Report (MMWR)

TARGETING RUBELLA FOR ELIMINATION IN INDIA

Full text description of Rubella burden of disease, vaccines vailable, efficacy and effectiveness of RA 27/3 vaccines in rubella and CRS elimination, duration of vaccine induced immunity, vaccine safe ...Source: Indian Journal of Public Health

WHO POSITION PAPER ON RUBELLA VACCINES

Full text description of background burden of disease, vaccines description and recoomendation of WHO that countries take the opportunity offered by accelerated measles control and elimination activit ...Source: Weekly Epidemiological Record (WER)

PROGRESS TOWARD CONTROL OF RUBELLA AND PREVENTION ...

Full text presentation of global progress in Rubella control and prevention of Congenital Rubella Sydrome. Annual reported cases of Rubella by region of WHO are presented with a comparative analysis o ...Source: Morbidity and Mortality Weekly Report (MMWR)

TWO DOSES OF MEASLES VACCINE REDUCE MEASLES DEATHS ...

This article outlines the importance of measles SIAs approach to delivery of the measles second dose, even in countries with health systems bottlenecks. Full text description of why measls SIAs   ...Source: Indian Paediatrics

MEASLES ELIMINATION IN THE AMERICAS: A COMPARISON ...

Considering to introduce a routine measles second dose? Then this is a must read for you. Full text details comparing countries that introduced MSD through routine and those without are available at: ...Source: Journal of Infectious Diseases

THE OPTIMAL AGE OF MEASLES IMMUNISATION IN LOW-INC ...

Considering increasing the age for measles vaccination to reap the benefits of higher sro-conversion rates in low transmission settings? Then this is a must read for you. Full text details on how mort ...Source: British Medical Journal

LABORATORY CHARACTERIZATION OF MEASLES VIRUS INFEC ...

This full text article describes clinical and serological bio-markers that one can use to differentiate measles in unvaccinated compared to secondary vaccine failures (SVF).  Clinically, there we ...Source: Journal of Infectious Diseases

SALIVARY DIAGNOSIS OF MEASLES: A STUDY OF NOTIFIED ...

Alternative specimen for measles diagnosis will increaisngly be needed as we draw nearer to the measles elimination goal. Saliva provides the easiest, safe and effective alternative to serum that requ ...Source: British Medical Journal

A POINT-OF-CARE TEST FOR MEASLES DIAGNOSIS: DETECT ...

A full text description of a novel point of care test for measles-specific IgM in serum and oral fluids shows that it is sensitive and specific on both sample types. In addition, the point of care tes ...Source: Bulletin of the World Health Organization

IMPACT OF MEASLES ELIMINATION ACTIVITIES ON IMMUNI ...

This report reviews the effects of accelerated measles elimination activities in six different countries and documents varied impacts (positive or deleterious). Desirable that accelerated measles elim ...Source: Journal of Infectious Diseases

ASSESSING THE COST-EFFECTIVENESS OF MEASLES ELIMIN ...

Using a dynamic age-structured compartmental model of measles transmission this report simulates scenarios and estimates health outcomes and costs for measles mortality reduction and measles eliminati ...Source: Journal of Infectious Diseases

SUPPLEMENTAL IMMUNIZATION ACTIVITIES (SIAS) IN SOU ...

Supplemental immunization activities in South Africa are reviewed with an epidemiological cost model to determine the cost-effectiveness of the 2010 campaign. This report documents variations in cost- ...Source: Global Health Action

RUBELLA VACCINATION OF UNKNOWINGLY PREGNANT WOMEN ...

Evidence suggesting that there is no risk of CRS in providing Rubella containing vaccines to mothers just before or during pregnancy. Full text available at http://jid.oxfordjournals.org/content/204 ...Source: Journal of Infectious Diseases

BURDEN OF CONGENITAL RUBELLA SYNDROME (CRS) IN IND ...

Full text review of Congenital Rubella Syndrome in India aimed at describing the prevalence and its contribution to long term handicaps. The study in addition estimates the susceptibility to Rubella i ...Source: Journal of Indian Paediatricts

IMPACT OF BIRTH RATE, SEASONALITY AND TRANSMISSION ...

This study looks at the policy recommendation to use Rubella vaccines in countries with heterogenous MCV coverage of 80%. Proposes the variable application of the policy based on other in-country para ...Source: Epidemiology and Infection

IMPLICATIONS OF SPATIALLY HETEROGENEOUS VACCINATIO ...

A review of hetergenous vaccination coverage and its effects on burden of Congenital Rubella Syndrome in South Africa. The study discusses the importance of private sector in RCV vaccinations and thus ...Source: Journal of the Royal Society Interface