Tuesday, 25th of May 2010 |
CSU 61/2010: THE RESEARCH AGENDA FOR MEASLES
Writing in the PanAfrican Medical Journal, Robin Biellik proposes research priorities for measles as the world moves from measles mortality reduction towards global eradication.
Also on the Net at http://www.panafrican-med-journal.com/content/editorial/5/11/
Good reading.
BD
Editorial
From Control to Elimination: the Research Agenda for Measles
Robin Biellik DrPH, Consultant Epidemiologist, Geneva, Switzerland
Correspondence address: rbiellik@gmail.com
Abstract
Five out of 6 WHO regions have set time-limited goals to move from regional measles mortality reduction to the regional elimination of indigenous transmission. Despite the abundance of research, there are a number of unanswered questions as we move towards a goal of measles elimination, many of which will be critical to achieving the elimination goal. We present here a list of research priorities from a programmatic and operational perspective.
Introduction
Research on measles virology, epidemiology, vaccine and vaccination strategies has expanded in recent years. Measles mortality reduction has already contributed significantly to progress towards the achievement of the 4th Millennium Development Goal to reduce <5 mortality by two thirds by 2015 compared with 1990 levels.[1] Interest in measles has increased with the increasing number of WHO regions (currently 5 out of 6, all except Southeast Asia) which have set time-limited goals to move from regional measles mortality reduction to the regional elimination of indigenous transmission. Indeed, the WHO Executive Board has requested studies on the feasibility of global measles eradication as a first step towards the possible establishment of a global goal.[2]
Despite the abundance of research, there are a number of unanswered questions as we move towards a goal of measles elimination, many of which will be critical to achieving the elimination goal. We present here a list of research priorities from a programmatic and operational perspective.
Measles epidemiology
· In certain settings, susceptible adolescents and young adults have played a significant role in measles outbreaks.[3] Therefore, will the achievement of measles elimination require greater attention to immunizing susceptible adolescents and young adults? Are older susceptibles more or less significant in urban, rural or highly isolated settings?
· In theory, the epidemiology of measles could alter in the absence of natural boosting by wild measles virus in highly vaccinated populations in the years following regional elimination and prior to global eradication (if that will eventually be achieved). If waning immunity is suspected in immunized populations, it will be necessary to verify immunity status through occasional serosurveys. If waning immunity is indeed detected, will adolescent or adult booster doses of measles vaccines be indicated?
· As measles transmission declines generally, the relative importance of nosocomial measles transmission will increase, and several nosocomial outbreaks have been identified in the past decade.[4,5] WHO guidelines for the prevention and control of nosocomial measles were established some years ago [6], but are not systematically implemented in many countries. Therefore, should greater emphasis be placed on vaccinating all infants attending out-patient clinics or admitted to hospital in communities where measles is circulating or where measles is considered likely to spread from neighbouring communities?
· WHO recommends that, where possible, HIV-positive infants and infants born to HIV-positive mothers should receive a measles dose at 6 months of age, in addition to the routine dose administered at 9 months of age. [1] Furthermore, in countries where an increasing number of HIV-positive children now receive anti-retroviral treatment and survive into adulthood, it is likely that secondary measles vaccine failure will begin to create significant new pools of susceptibles.[6] Therefore, do countries with high HIV seropositivity in children need to consider modifying measles control policies, including the need for “booster” doses?
Measles surveillance
· Experience from other vaccine-preventable disease initiatives has shown that the establishment of case-based, laboratory-based surveillance is essential as we move from disease control to elimination. Therefore, what are the critical surveillance indicators for measuring progress toward elimination and maintenance of elimination? What is the sensitivity and specificity of the proposed set of the ‘elimination certification’ criteria and of each criterion alone? Is it epidemiologically useful and cost-effective to continue conducting extensive genetic characterization of vaccine viruses? Are there benefits to be reaped from showing a declining number of genetic lineages?
· WHO currently recommends the use of measles IgM serology for case confirmation in surveillance in countries that adopt measles mortality reduction or elimination goals.[8] However, in recent years, alternative methods measuring measles IgG in dried blood-spots and oral fluid with improved sensitivity and specificity have become available that have demonstrated value for establishing population immunity to measles have become available.[9] These approaches are more acceptable because they avoid the need for venipuncture. The costs of specimen collection and laboratory assays for serum specimens, dried blood-spots and oral fluid are currently roughly similar.[10] Would it be operationally simpler to switch to oral fluid specimens for laboratory confirmation of measles?
Vaccination strategies
· We know that in developing countries where the first dose of measles vaccine is administered to infants <12 months of age, a second dose is required to eliminate susceptibles from the population and interrupt measles transmission.[11] Under field conditions, what levels of 1st and 2nd dose vaccination coverage will interrupt measles transmission?
· In most developing countries, the 2nd measles dose is currently delivered through a mass campaign strategy that is repeated when a critical mass of new susceptibles is estimated to have entered the population .[11] Current practice is to space measles campaigns at intervals of three years. Can the attached 1996 graphic [12] be improved upon?
Furthermore, what is the ideal age, from both the epidemiological and operational perspectives, for the administration of the 2nd dose? In the Mideast, the second routine dose is more often given on school entry than in the second year of life. Is this policy more widely applicable?
· Increasingly, developing countries are considering delivering the 2nd measles dose through the routine immunization programme, for operational convenience. Are the same levels of 1st and 2nd dose vaccination coverage required to interrupt measles transmission, regardless of the delivery strategy adopted for the 2nd dose?
· Does measles vaccination coverage increase or decrease when mass measles campaigns are integrated with the delivery of other public health interventions such as ITN distribution or with other contacts with eligible children such as Child Health Days? In particular, what are the possible advantages of giving measles vaccination at the same time as malaria bednet distribution?
· Can very large countries, such as Nigeria, Indonesia, China and India, follow the same strategy as other countries, in particular simultaneous nationwide campaigns? Vaccinating 50 to 100 million children in a single week presents special challenges, both from the operational and from the vaccine supply standpoints.
· The PAHO model for integrated measles and rubella elimination is applicable only where countries adopt the PAHO objective of regional rubella elimination. When countries introduce rubella vaccination, either for control or, as in the Americas, for elimination, what is the best approach to harmonizing approaches to rubella and measles vaccination?
· The house-to-house approach is fundamental to polio eradication, but not, at present, to measles. Can countries with weak health infrastructures interrupt measles transmission without such practices as preregistration of vaccinees and house-to-house mobilization?
Alternative vaccine delivery technologies
· What are the possible policy changes if needleless measles vaccine, given as an aerosol, is licensed and commercialized? Will measles campaign approaches more closely resemble the door-to-door approach of polio campaigns? In the event that India, for example, licensed needleless technology, what field studies would be needed to fit the new technology into the existing strategies?
Co-administration of measles vaccine with other vaccines
• How does the co-administration measles vaccine with other vaccines (e.g., yellow fever, Japanese encephalitis, tetanus toxoid, etc.) affect vaccine safety and immunogenicity?
Acknowledgements
The author gratefully acknowledges technical advice received from Robert Davis MPH, Measles Delegate, American Red Cross, Nairobi, Kenya
Conflicts of interest
The author reports no conflicts of interest.
References
[1] WHO. 2008a. “Progress in global measles control and mortality reduction, 2000–2007,” Wkly Epidemiol Rec 2008; 83:441–448.
[2] WHO. 2009. “Executive Board 125th Session, agenda item 5.1”. WHO/EB/125/4, 16 April 2009. http://apps.who.int/gb/ebwha/pdf_files/EB125/B125_4-en.pdf and http://apps.who.int/gb/ebwha/pdf_files/EB126/B126_17‐en.pdf
[3] Pan-American Health Organization. “Update: Sao Paulo Measles Outbreak” in EPI Newsletter, 20:1, February 1998, 5-6, viewed on 20 January 2009 at www.paho.org/nenglish/hvp/hvi/sne2001.pdf .
[4] Chen J, Tsou T, Liu D. “Measles resurgence in Taiwan – lessons learned” J Formos Med Assoc 2009;108(4):267-269
[5] Follin P et al., “Effective control measures limited measles outbreak after extensive nosocomial exposures in January-February 2008 in Gothenburg, Sweden,” Eurosurveillance 2009, 30.
[6] WHO. 1995. Measles control in the 1990s: minimising nosocomial transmission. WHO publication WHO/EPI/GEN/95.4.
[7] Scott S, Mossong J, Moss W, Cutts F, Cousens S. Predicted impact of the HIV-1 epidemic on measles in developing countries: results from a dynamic age-structured model Int J Epid 2008; 37:356–367
[8] Guris G. “Module on best practices for measles surveillance”. WHO; 2001. http://www.who.int/vaccines-documents/DocsPDF01/www617.pdf .
[9] Biellik R, Brown D. “Commentary: Measles mortality reduction in Africa.” Lancet 21 March 2009; 984-985.
[10] WHO. 2008b. “Measles and rubella laboratory network: 2007 meeting on use of alternative sampling techniques for surveillance” Wkly Epidemiol Rec 2008; 83: 229–232.
[11] WHO-UNICEF. Measles mortality reduction and regional elimination strategic plan 2001-2005. Geneva, 2001; WHO/V&B/01.13 Rev 1.
[12] de Quadros C et al. “Measles Elimination in the Americas,” JAMA 17 Jan 1996; 224-229. |
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