Adverse Events Following Immunization in Brazil: Age of Child and Vaccine-Associated Risk Analysis Using Logistic Regression.

Thursday, 14th of June 2018 Print

Int J Environ Res Public Health. 2018 Jun 1;15(6). pii: E1149. doi: 10.3390/ijerph15061149.

Adverse Events Following Immunization in Brazil: Age of Child and Vaccine-Associated Risk Analysis Using Logistic Regression.

Lopes SRC1 Perin JLR2 Prass TS3 Carvalho SMD4 Lessa SC5 Dórea JG6.

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Abstract

Objective: Vaccines are effective in controlling and eradicating infectious diseases. However adverse events following immunization (AEFI) can occur in susceptible individuals. The objective of this study was to analyze the Brazilian AEFI database and compare eight vaccines in order to profile risks of AEFIs related to the mandated pediatric schedule of immunization considering the age and sex of the child type of vaccine and reported adverse events. Methods: We analyzed the Brazilian AEFI database integrating reports between 2005 and 2010 for children less than 10-years old immunized with eight mandated vaccines: diphtheria pertussis tetanus Haemophilus influenzae type b (TETRA); diphtheria tetanus and pertussis (DTP); Bacillus Calmette⁻Guerin (BCG); oral poliovirus vaccine (OPV); measles mumps and rubella (MMR); oral rotavirus vaccine (ORV); hepatitis B (HB); and yellow fever (YF). We compared the childrens age regarding types of AEFI evaluated AEFI factors associated with the chance of hospitalization of the child and estimated the chance of notification of an AEFI as a function of the type of vaccine. In total 47105 AEFIs were observed for the mandated vaccines. Results: The highest AEFI rate was for the TETRA vaccine and the lowest was for the OPV vaccine with 60.1 and 2.3 events per 100000 inoculations respectively. The TETRA vaccine showed the highest rate of hypotonic hypo responsive episode followed by convulsion and fever. The MMR and YF vaccines were associated with generalized rash. BCG was associated with enlarged lymph glands but showed the largest negative (protective) association with hypo responsive events and seizures. Compared with children aged 5⁻9-years old young children (.

KEYWORDS:

AEFI; adverse event; immunization; passive surveillance; vaccine

PMID: 29865181 DOI: 10.3390/ijerph15061149

 

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