Multivalent and multipathogen vaccines delivered by viral vectors.

Monday, 29th of August 2016

Clin Vaccine Immunol. 2016 Aug 17. pii: CVI.00298-16. [Epub ahead of print]

Multivalent and multipathogen vaccines delivered by viral vectors.

Lauer KB¹ Borrow R² Blanchard TJ³.

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Abstract

The presentation and delivery of antigens is crucial for inducing immunity and desirably lifelong protection. Recombinant viral vectors - proven safe and successful in veterinary vaccine applications - are ideal shuttles for delivering foreign proteins to induce an immune response with protective antibody levels by mimicking natural infection. Some examples of viral vectors are adenoviruses measles virus or poxviruses. The required attributes to qualify as a vaccine vector are: Stable insertion of coding sequences into the genome induction of a protective immune response a proven safety record and the potential for large scale production. The need to develop new vaccines for infectious diseases increase vaccine accessibility reduce health costs and simplify overloaded immunisation schedules has driven the idea to combine antigens from the same or various pathogens. To protect effectively some vaccines require multiple antigens of one pathogen or different pathogen serotypes/serogroups in combination (multivalent or polyvalent vaccines). Future multivalent vaccine candidates are likely to be required for complex diseases like malaria and HIV. Other novel strategies propose antigen combination of different pathogens to protect against several diseases at once (multidisease or multipathogen vaccines).

Copyright © 2016 American Society for Microbiology. All Rights Reserved

This article is a pay per view, URL: http://www.ncbi.nlm.nih.gov/pubmed/27535837

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