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Mem Inst Oswaldo Cruz. 2014 Jun109(3):335-9. Epub 2014 May 7.
Santos EM1 Silva e Sá GR1 Siqueira MM2 Martins Rde M1 Camacho LA2 von Doellinger Vdos R1Maia Mde L1.
A non-controlled longitudinal study was conducted to evaluate the combined vaccine against measles mumps and rubella (MMR) immunogenicity in 150 children vaccinated in the routine of three health units in the city of Rio de Janeiro Brazil 2008-2009 without other vaccines administered during the period from 30 days before to 30 days after vaccination. A previous study conducted in Brazil in 2007 in 1769 children ranging from 12-15 months of age vaccinated against yellow fever and MMR simultaneously or at intervals of 30 days or more between doses had shown low seroconversion for mumps regardless of the interval between administration of the two vaccines. The current study showed 89.5% (95% confidence interval: 83.3; 94.0) seroconversion rate for mumps. All children seroconverted for measles and rubella. After revaccination high antibody titres and seroconversion rates were achieved against mumps. The results of this study and others suggest that two MMR doses confer optimal immune responses for all three antigens and the possible need for additional doses should be studied taking into account not only serological but also epidemiological data as there is no serological correlate of protection for mumps.