Differential Induction of Type I Interferons in Macaques by Wild-type Measles Virus or Wild-type Measles Virus with the Hemagglutinin Protein of the Edmonston Vaccine strain.

Thursday, 16th of June 2016 Print

Microbiol Immunol. 2016 Jun 9. doi: 10.1111/1348-0421.12392. [Epub ahead of print]

Differential Induction of Type I Interferons in Macaques by Wild-type Measles Virus or Wild-type Measles Virus with the Hemagglutinin Protein of the Edmonston Vaccine strain.

Nguyen NV1 Kato SI1 Nagata K1 Takeuchi K2.

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Abstract

Measles vaccines are highly effective and safe but the mechanism underlying their attenuation has not been well understood. In this study type I interferons (IFNs) (IFN-α and IFN-β) induction in macaques infected with measles virus (MV) strains was examined. Type I IFNs were not induced in macaques infected with wild-type MV. However IFN-α was sharply induced in most of macaques infected with the recombinant wild-type MV bearing the hemagglutinin (H) protein of the Edmonston vaccine strain. These results indicate that the H protein of MV vaccine strains may have a role in MV attenuation.

© 2016 The Societies and John Wiley & Sons Australia Ltd.

 

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