Measles elimination in Italy: data from laboratory activity 2011-2013.

Tuesday, 29th of March 2016 Print

J Clin Virol. 2015 Mar;64:34-9. doi: 10.1016/j.jcv.2014.12.019. Epub 2014 Dec 31.

Measles elimination in Italy: data from laboratory activity 2011-2013.

Magurano F1 Baggieri M2 Fortuna C3 Bella A4 Filia A5 Rota MC6 Benedetti E7 Bucci P8 Marchi A9 Nicoletti L10.

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Abstract

BACKGROUND:

The European Regional Office of the World Health Organization developed a strategic approach to halt the indigenous transmission of measles in its 53 Member States by 2015 World Health Organization [1]. Many European countries including Italy began the implementation of national programs to reach this goal.

OBJECTIVES:

To describe and discuss the results of laboratory activity in measles surveillance performed from January 2011 to December 2013 by the Italian National Reference Laboratory for Measles and Rubella.

STUDY DESIGN:

Samples of suspected measles cases were collected from different Italian regions to confirm clinical diagnosis. Anti-measles IgM antibodies detection by Enzyme-Linked Immunosorbent Assay and/or molecular detection by Reverse Transcriptase-Polymerase Chain Reaction assay were performed. Positive samples were sequenced for viral characterization.

RESULTS AND CONCLUSIONS:

According to results from the National Reference Laboratorys activity urine and blood seem to be the best specimens for measles laboratory surveillance. Phylogenetic analysis revealed a co-circulation of the genotypes D4 and D8 during the reviewed period a cluster of B3 and sporadic cases of D9 and H1.

 

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