Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature.

Tuesday, 29th of March 2016 Print

J Matern Fetal Neonatal Med. 2016 Mar 22:1-14. [Epub ahead of print]

Fetal and neonatal abnormalities due to congenital rubella syndrome: a review of literature.

Yazigi A1 Eldin De Pecoulas A1 Vauloup-Fellous C2 Grangeot-Keros L2 Ayoubi JM13 Picone O13.

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Abstract

OBJECTIVE:

Rubella virus infection during the first trimester of pregnancy can cause congenital rubella syndrome (CRS). We aimed to describe the abnormalities in order to define the ultrasound features to look for when performing prenatal scans. The goal of this review is to focus specifically on the signs of CRS accessible to prenatal diagnosis.

METHODS:

We analyzed every case of CRS described before and/or after birth that we identified in the Pubmed database and classified them as accessible or not to prenatal diagnosis.

RESULTS:

The most frequently reported malformations accessible to prenatal diagnosis were: cardiac septal defects pulmonary artery stenosis microcephaly cataract microphtalmia and hepatosplenomegaly.

CONCLUSION:

This extensive literature review shows that the ultrasound features of CRS are not well known even though rubella was the first teratogenic virus described. This review will help clinicians in the management of rubella during pregnancy by clarifying the findings to be sought.

 

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