Rubella immunity in women of childbearing age, eight years after the immunization program in iran.

Monday, 21st of March 2016

Iran Red Crescent Med J. 2014 Jul;16(7):e10431. doi: 10.5812/ircmj.10431. Epub 2014 Jul 5.

Rubella immunity in women of childbearing age eight years after the immunization program in iran.

Barari Sawadkohi R¹ Zarghami A² Izadpana F² Pournasrollah M³.

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Abstract

BACKGROUND:

Rubella is a viral disease with a worldwide distribution. Mass vaccination campaigns have increased the vaccine coverage in the world with substantial impact on reduction of rubella infections. In Iran the national measles-rubella campaign targeting individuals 5-25 years old was initiated in 2003 and mass childhood vaccination against measles rubella and mumps has continued ever since.

OBJECTIVES:

The aim of this study was to evaluate the efficacy of routine vaccination on rubella immunity among women of childbearing age in Babol north of Iran.

PATIENTS AND METHODS:

This cross-sectional study was conducted on 812 women of childbearing age living in Babol north of Iran in 2011. Twelve samples were excluded from the study because of inadequate sera amounts. Serum samples were examined for presence of rubella-specific IgG antibodies by means of quantitative ELISA.

RESULTS:

From a total of 800 samples in this study rubella IgG seropositivity was seen in 786 (98.3% [95% CI = %97.5-%99.1]) cases. The maximum IgG seropositivity (99.2%) was seen in the age group of 21-25 years old and the lowest immunity (87.7%) was in the group of above 30 years old.

CONCLUSIONS:

Our data indicated that the rate of seropositivity to rubella virus in our population was high suggesting that vaccination has been successful in Babol reducing the likelihood of congenital rubella infection.