Molecular Characterization of Wild Type Measles Virus from Adult Patients in Northern China, 2014.

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Int J Infect Dis. 2016 Feb 16. pii: S1201-9712(16)00028-X. doi: 10.1016/j.ijid.2016.02.008. [Epub ahead of print]

Molecular Characterization of Wild Type Measles Virus from Adult Patients in Northern China 2014.

Xu W¹ Zhang MX² Qin EQ¹ Yan YC² Li FY¹ Xu Z¹ Tian X² Fan R¹ Tu B¹ Chen WW³ Zhao M⁴.

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Abstract

OBJECTIVES:

In this study we studied the N and H genes from wild type measles viruses (MeVs) isolated during the 2013-2014 outbreak.

METHODS:

Clinical samples were collected and the genotyping phylogenetic analysis were performed.

RESULTS:

The vaccination rate of the study population was 4%. Genotype H1a was the predominant genotype. Wild type viruses were classified into clusters A and B C and may have different origins. N-450 sequences from wild type viruses were highly homologous with and likely evolved from MeVs circulating in Tianjing and Henan in 2012. MVs/Shenyang.CHN/18.14/3 could have evolved from MeVs from Liaoning Beijing Hebei Heilongjiang Henan Jilin and Tianjin. Our data suggested that one or more of the same viruses circulated between Beijing Shenyang Hong Kong Taiwan and Berlin.

CONCLUSIONS:

Important factors contributing to outbreaks could include weak vaccination coverage poor vaccination strategies and migration of adult workers between cities countries and from rural areas to urban areas.