Variability in Humoral Immunity to Measles Vaccine: New Developments.
| Friday, 11th of December 2015 |
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Variability in Humoral Immunity to Measles Vaccine: New Developments.
Haralambieva IH Kennedy RB Ovsyannikova IG Whitaker JA Poland GA.
http://www.ncbi.nlm.nih.gov/pubmed/26602762
Abstract
Despite the existence of an effective measles vaccine resurgence in measles cases in the USA and across Europe has occurred including in individuals vaccinated with two doses of the vaccine. Host genetic factors result in inter-individual variation in measles vaccine-induced antibodies and play a role in vaccine failure. Studies have identified HLA (human leukocyte antigen) and non-HLA genetic influences that individually or jointly contribute to the observed variability in the humoral response to vaccination among healthy individuals. In this exciting era new high-dimensional approaches and techniques including vaccinomics systems biology GWAS epitope prediction and sophisticated bioinformatics/statistical algorithms provide powerful tools to investigate immune response mechanisms to the measles vaccine. These might predict on an individual basis outcomes of acquired immunity post measles vaccination.
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