Monitoring of timely and delayed vaccinations: a nation-wide registry-based study of Norwegian children aged < 2 years.

Thursday, 19th of November 2015

Monitoring of timely and delayed vaccinations: a nation-wide registry-based study of Norwegian children aged < 2 years.

Riise ØR¹ Laake I² Bergsaker MA³ Nøkleby H⁴ Haugen IL⁵ Storsæter J⁶.

 

Abstract

BACKGROUND:

Delayed vaccinations increase the risk for vaccine preventable diseases (VPDs). Monitoring of delayed vaccinations by using a national immunisation registry has not been studied in countries recommending a two-dose (3 and 5 months of age) primary series of e.g. pertussis vaccine. Surveillance/monitoring of all vaccinations may improve vaccination programmes functioning.

METHODS:

We obtained information from the Norwegian immunisation registry (SYSVAK) on all programme vaccinations received at age up to 730 days in children born in 2010 (n = 63382). Timely vaccinations were received up to 7 days after the recommended age. Vaccinations were considered delayed if they were received more than one month after the recommended age in the schedule.

RESULTS:

In vaccinated children timely administration of the subsequent three doses of pertussis and one dose of measles occurred in 73.8 47.6 53.6 and 43.5 % respectively. Delay for one or more programme vaccinations (diphtheria tetanus pertussis polio Haemophilus influenza type B invasive pneumococcal disease measles mumps or rubella) was present in 28336 (44.7 %) children. Among those who were delayed the mean duration was 139 days. The proportion of children that had vaccinations delayed differed among counties (range 37.4 %-57.8 %). Immigrant children were more frequently delayed 52.3 % vs. 43.1 % RR 1.21 (95 % CI 1.19 1.24). Children scheduled for vaccines in the summer holiday month (July) were more frequently delayed than others (1(st) dose pertussis vaccine 6.5 % vs. 3.9 % RR 1.65 (95 % CI 1.48 1.85). Priming against pertussis (2(nd) dose) pneumococcal (2(nd) dose) and measles (1(st) dose) was delayed in 16.8 18.6 and 29.3 % respectively.

CONCLUSION:

Vaccinations were frequently delayed. Delayed vaccinations differed among counties and occurred more frequently during the summer vacation (July) and in the immigrant population. Monitoring improves programme surveillance and may be used on an annual basis.