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Public Health Interventions to Reduce the Secondary Spread of Measles
Full text is at http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0078260/pdf/PubMedHealth_PMH0078260.pdf
This extensive literature review, by the Canadian Agency for Drugs and Technologies in Health, sought to answer the following research questions.
1.What is the clinical effectiveness associated with delivery of measles vaccine to susceptible measles contacts?
2.What is the clinical effectiveness associated with immunoglobulin
delivery to susceptible measles contacts?
3.What is the clinical effectiveness associated with quarantine of susceptible measles contacts?
4.What is the clinical effectiveness associated with isolation of communicable measles cases?
5.What is the clinical effectiveness of targeted measles vaccination activities during an outbreak?
“. . .The strongest available evidence relates to administration of measles-containing vaccine, with four of five included studies demonstrating a potential benefit (two reaching statistical significance) and the fifth small study (n = 6) demonstrating no benefit.”