MUMPS POSTEXPOSURE PROPHYLAXIS WITH A THIRD DOSE OF MEASLES-MUMPS-RUBELLA VACCINE, ORANGE COUNTY, NEW YORK, USA.

Monday, 2nd of June 2014

[source]Emerging Infectious Diseases[|source]

In this report, the authors  assess secondary mumps attack rates among Orthodox Jewish household contacts in Orange County, New York, who received PEP with a third dose of MMR vaccine within 5 days of mumps introduction into a household by a family member, and compare them with household contacts of persons who had received 2 previous MMR doses and did not receive PEP. The report documents that although 2 MMR doses are sufficient for preventing mumps in most settings, administering a third MMR dose may be worthwhile in specific outbreak contexts, even if it does not offer protection as PEP. More details are accessible at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810923/

 

ABSTRACT

Although the measles-mumps-rubella (MMR) vaccine is not recommended for mumps postexposure prophylaxis (PEP), data on its effectiveness are limited. During the 2009-2010 mumps outbreak in the northeastern United States, we assessed effectiveness of PEP with a third dose of MMR vaccine among contacts in Orthodox Jewish households who were given a third dose within 5 days of mumps onset in the households index patient. We compared mumps attack rates between persons who received a third MMR dose during the first incubation period after onset in the index patient and 2-dose vaccinated persons who had not. Twenty-eight (11.7%) of 239 eligible household members received a third MMR dose as PEP. Mumps attack rates were 0% among third-dose recipients versus 5.2% among 2-dose recipients without PEP (p=0.57). Although a third MMR dose administered as PEP did not have a significant effect, it may offer some benefits in specific outbreak contexts.