AEROSOLIZED ADENOVIRUS VECTORED VACCINE AS AN ALTERNATIVE VACCINE DELIVERY METHOD.

Tuesday, 30th of July 2013

[source]Respiratory Research[|source]

In this article, the authors report on an experiement that use adenoviruses asvectors to deliver influenza vaccines. If successful, this technology could then be easily used by measles vaccine delivery as alternative delivery options are being sought. If the read on this innovation excites you, then visit the following site for more details:  http://respiratory-research.com/content/12/1/153

 

 

Abstract

Conventional parenteral injection of vaccines is limited in its ability to induce locally produced immune responses in the respiratory tract, and has logistical disadvantages in widespread vaccine administration. Recent studies suggest that intranasal delivery or vaccination in the respiratory tract with recombinant viral vectors can enhance immunogenicity and protection against respiratory diseases such as influenza and tuberculosis, and can offer more broad-based generalized protection by eliciting durable mucosal immune responses. Controlled aerosolization is a method to minimize vaccine particle size and ensure delivery to the lower respiratory tract. Here, we characterize the dynamics of aerosolization and show the effects of vaccine concentration on particle size, vector viability, and the actual delivered dose of an aerosolized adenoviral vector. In addition, we demonstrate that aerosol delivery of a recombinant adenoviral vaccine encoding H1N1 hemagglutinin is immunogenic and protects ferrets against homologous viral challenge. Overall, aerosol delivery offers comparable protection to intramuscular injection, and represents an attractive vaccine delivery method for broad-based immunization campaigns.