INCREASING THE TIME OF EXPOSURE TO AEROSOL MEASLES VACCINE ELICITS AN IMMUNE RESPONSE EQUIVALENT TO THAT SEEN IN 9 MONTH OLD MEXICAN CHILDREN GIVEN THE SAME DOSE SUBCUTANEOUSLY.

Tuesday, 30th of July 2013

[source]Journal of Infectious Diseases[|source]

In this article, the authors further the understanding on aerosol measles vaccines. They report on an experiement that increasing the duration of exposure to the aerosol measles vaccine improves sero-response (serum nutralizing antibodies and memory) to levels equivalent  or even better than sub-cutaneous vaccination route. Hope this review excites your interest in alternative measles vaccine delivery technologies, currently under development. More details available at:  http://jid.oxfordjournals.org/content/204/3/426.long

 

 

Abstract

BACKGROUND: A 30-second aerosol measles vaccination successfully primes children 12 months of age and older but is poorly immunogenic when given to 9 months old children. We examined the immune responses when increasing the duration to aerosol exposure in 9 months old children.

METHODS: One hundred and thirteen healthy 9 months old children from Mexico City were enrolled; 58 received aerosol EZ measles vaccine for 2.5 minutes and 55 subcutaneously. Measles-specific neutralizing antibodies and cellular responses were measured before and at 3 and 6 months postimmunization.

RESULTS: Adaptive immunity was induced in 97% after aerosol and 98% after subcutaneous administration. Seroconversion rates and GMCs were 95% and 373 mIU/mL (95% confidence interval [CI], 441-843) following aerosol vaccination and 91% and 306 mIU/mL (95% CI, 367-597) after subcutaneous administration at 3 months. The percentage of children with a measles-specific stimulation index ≥3 was 45% and 60% in the aerosol versus 55% and 59% in the subcutaneous group at 3 and 6 months, respectively. CD8 memory cell frequencies were higher in the aerosol group at 3 months compared with the subcutaneous group. Adverse reactions were comparable in both groups.

CONCLUSIONS: Increasing exposure time to aerosol measles vaccine elicits immune responses that are comparable to those seen when an equivalent dose is administered by the subcutaneous route in 9 months old infants