MEASLES IMMUNOMETRICS

Sunday, 30th of December 2012 Print
[source]Proceedings of the National Academy of Sciences of the United States of America[|source]

Abstract below; full text is at  http://www.pnas.org/content/109/37/14724.full

Measles Virus (MV) infection results in transient viremia that is cleared within approximately 2 weeks, coincident with CD8+ T-cell responses. MV RNA persists, however, for as long as months in blood. In the acute phase of infection, most MV is likely produced by infected lymphocytes. The source of persistent MV RNA is unknown, but could come from infected lymphocytes, follicular dendritic cells, or possibly other cell types, including epithelial cells in lung, liver, or kidney. Lin et al.’s modeling studies point to an important role for antibodies in clearing persistently infected cells that are the source of MV RNA.

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